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The present study investigated the antimicrobial and antioxidant activities as well as the chemical composition of the methanolic extracts of Spirogyra setiformis and Navicula spp. found in Nigerian waters. The minimum inhibitory concentration (MIC) of the methanolic extracts of the algae were determined against 7 clinical isolates (Enterococcus faecalis, Staphylococcus aureus ATCC 25923, Bacillus cereus, Klebsiella pneumoniae, Salmonella typhi, Escherichia coli ATCC 25922 and Candida albicans) using the broth dilution method. The antioxidant activity of the algae extract was assessed using 1,1-diphenyl-1-picrylhydrazyl, nitric oxide and reducing power assays. The volatile constituents of the extracts were also analysed using GC–MS. The results revealed that the S. setiformis extract inhibited all the clinical isolates except S. typhi and C. albicans while Navicula spp. had inhibitory effects on all the test isolates. The MIC values of the algae extracts varied between 2.0 mg/L and 10.0 mg/L. Both extracts showed potent free radical scavenging activities evidenced in DPPH, nitric oxide and reducing power assays. A total of 16 and 11 volatile compounds were obtained from S. setiformis and Navicula spp., respectively. The major component in S. setiformis was 11,14,17-methyl ester eicosatrienoic and trans-geranyl geraniol in Navicula spp. These findings suggest that these indigenous algae species could be good sources of antimicrobial and antioxidant agents.
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